| 1. Round | 31/07/2021 | Dundee FC | - | St. Mirren FC | 2:2 |  |
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| 2. Round | 07/08/2021 | St. Mirren FC | - | Heart of Midlothian | 1:2 | ||||
| 3. Round | 21/08/2021 | Celtic FC | - | St. Mirren FC | 6:0 |  |
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| 4. Round | 29/08/2021 | St. Mirren FC | - | St. Johnstone FC | 0:0 | ||||
| 5. Round | 11/09/2021 | St. Mirren FC | - | Dundee United | 0:0 | ||||
| 6. Round | 18/09/2021 | Hibernian FC | - | St. Mirren FC | 2:2 | ||||
| 7. Round | 26/09/2021 | St. Mirren FC | - | Aberdeen FC | 3:2 | ||||
| 8. Round | 02/10/2021 | Livingston FC | - | St. Mirren FC | 0:1 | ||||
| 9. Round | 16/10/2021 | Ross County FC | - | St. Mirren FC | 2:3 | ||||
| 10. Round | 24/10/2021 | St. Mirren FC | - | Rangers FC | 1:2 | ||||
| 13. Round | 06/11/2021 | St. Johnstone FC | - | St. Mirren FC | 0:0 | |
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| 14. Round | 20/11/2021 | St. Mirren FC | - | Livingston FC | 1:1 | |
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| 15. Round | 27/11/2021 | Heart of Midlothian | - | St. Mirren FC | 2:0 | ||||
| 16. Round | 01/12/2021 | St. Mirren FC | - | Ross County FC | 0:0 | ||||
| 17. Round | 04/12/2021 | Aberdeen FC | - | St. Mirren FC | 4:1 | ||||
| 18. Round | 11/12/2021 | St. Mirren FC | - | Hibernian FC | 1:1 | ||||
| 20. Round | 26/12/2021 | Rangers FC | - | St. Mirren FC | 2:0 | ||||
| 23. Round | 25/01/2022 | St. Mirren FC | - | Aberdeen FC | 1:0 |
Ireland