| 1. Round | 13/02/2021 | Unión de Santa Fe | - | Atlético Tucumán | 2:2 |  |
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| 2. Round | 22/02/2021 | Atlético Tucumán | - | Central Córdoba SdE | 1:2 | ||||
| 3. Round | 02/03/2021 | Atlético Tucumán | - | Huracán | abor. | ||||
| 4. Round | 06/03/2021 | Lanús | - | Atlético Tucumán | 2:1 | ||||
| 5. Round | 15/03/2021 | Atlético Tucumán | - | Patronato de Paraná | 4:2 | ||||
| 7. Round | 30/03/2021 | Atlético Tucumán | - | Newell's Old Boys | 2:2 | ||||
| 8. Round | 03/04/2021 | Sarmiento de Junín | - | Atlético Tucumán | 1:2 |  |
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| 9. Round | 13/04/2021 | Atlético Tucumán | - | Vélez Sarsfield | 2:0 | ||||
| 10. Round | 17/04/2021 | Boca Juniors | - | Atlético Tucumán | 3:1 | ||||
| 11. Round | 26/04/2021 | Atlético Tucumán | - | Talleres de Córdoba | 2:3 | ||||
| 12. Round | 02/05/2021 | Independiente | - | Atlético Tucumán | 0:1 | |
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| 13. Round | 08/05/2021 | Atlético Tucumán | - | Defensa y Justicia | 5:0 | |
Argentina