| 1. Round | 28/08/2021 | SBV Excelsior [U21] | - | Willem II [U21] | 0:1 |  |
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| 3. Round | 18/09/2021 | FC Emmen [U21] | - | Willem II [U21] | 3:4 | ||||
| 4. Round | 25/09/2021 | Willem II [U21] | - | Alphense Boys [U21] | 5:2 | ||||
| 6. Round | 16/10/2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 7. Round | 22/10/2021 | Vitesse [U21] | - | Willem II [U21] | 1:3 | ||||
| 9. Round | 06/11/2021 | Alphense Boys [U21] | - | Willem II [U21] | 0:3 | ||||
| 10. Round | 20/11/2021 | Willem II [U21] | - | Vitesse [U21] | 4:1 | ||||
| 11. Round | 27/11/2021 | PEC Zwolle [U21] | - | Willem II [U21] | 2:2 | ||||
| 12. Round | 05/02/2022 | Willem II [U21] | - | SBV Excelsior [U21] | 1:2 | ||||
| 13. Round | 12/02/2022 | Willem II [U21] | - | FC Emmen [U21] | 1:2 |
Netherlands