| 1. Round | 16/07/2021 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 | ||||
| 14. Round | 01/10/2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 | ||||
| 15. Round | 11/10/2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
| 18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 24. Round | 06/12/2021 | Independiente II | - | San Lorenzo II | 1:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |  |
Argentina
Wales