| 1. Round | 12/02/2021 | San Lorenzo II | - | Arsenal de Sarandí II | 3:0 | ||||
| 2. Round | 19/02/2021 | Colón de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 3. Round | 26/02/2021 | San Lorenzo II | - | Central Córdoba SdE II | 2:1 | ||||
| 4. Round | 05/03/2021 | San Lorenzo II | - | Huracán II | 2:2 | ||||
| 5. Round | 12/03/2021 | Banfield II | - | San Lorenzo II | 2:1 | ||||
| 6. Round | 19/03/2021 | San Lorenzo II | - | Aldosivi II | 0:1 | ||||
| 10. Round | 16/04/2021 | San Lorenzo II | - | Argentinos Juniors II | 2:2 | ||||
| 12. Round | 30/04/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 |
Argentina