| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 |  |
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| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | ||||
| 6. Round | 21/08/2021 | Club León [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 7. Round | 28/08/2021 | Club León [U20] | - | CF América [U20] | 2:2 | ||||
| 12. Round | 02/10/2021 | Club León [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Round | 20/10/2021 | Club León [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 15. Round | 23/10/2021 | Puebla FC [U20] | - | Club León [U20] | 2:1 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 17. Round | 06/11/2021 | Club León [U20] | - | Club Necaxa [U20] | 3:1 |
Mexico