| 2. Round | 02/08/2021 | Atlético San Luis [U20] | - | Gallos Blancos [U20] | 0:2 |  |
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| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | |
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| 4. Round | 14/08/2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 | |
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| 11. Round | 29/09/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 12. Round | 03/10/2021 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 2:0 | ||||
| 13. Round | 14/10/2021 | Gallos Blancos [U20] | - | Club Tijuana [U20] | 3:3 | ||||
| 14. Round | 19/10/2021 | Gallos Blancos [U20] | - | CF Monterrey [U20] | 1:1 | |
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| 15. Round | 22/10/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 16. Round | 30/10/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 0:5 |  |
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| 17. Round | 04/11/2021 | Atlas Guadalajara [U20] | - | Gallos Blancos [U20] | 1:1 |
Mexico