| 1. Round | 31/07/2021 | Pumas Tabasco | - | Alebrijes de Oaxaca | 0:0 |  |
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| 4. Round | 17/08/2021 | Mineros de Zacatecas | - | Pumas Tabasco | 1:2 | ||||
| 7. Round | 09/09/2021 | Pumas Tabasco | - | Atlante | 0:2 | ||||
| 13. Round | 20/10/2021 | Pumas Tabasco | - | Cancún FC | 0:0 | ||||
| 14. Round | 29/10/2021 | Atlético Morelia | - | Pumas Tabasco | 0:1 |  |
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| 15. Round | 07/11/2021 | CF Monterrey II | - | Pumas Tabasco | 1:1 | ||||
| 16. Round | 11/11/2021 | Pumas Tabasco | - | Tepatitlán | 1:1 |
Mexico