| 2. Round | 23/07/2022 | FC Zürich | - | FC Luzern | 0:0 | ||||
| 4. Round | 07/08/2022 | FC Lugano | - | FC Luzern | 1:2 | ||||
| 1. Round | 10/08/2022 | FC Luzern | - | Grasshopper Club Zürich | 1:1 | ||||
| 5. Round | 13/08/2022 | FC St. Gallen | - | FC Luzern | 4:1 | ||||
| 6. Round | 27/08/2022 | FC Luzern | - | FC Sion | 2:0 | ||||
| 7. Round | 04/09/2022 | FC Luzern | - | Servette FC | 0:2 | ||||
| 8. Round | 10/09/2022 | FC Winterthur | - | FC Luzern | 0:6 | ||||
| 10. Round | 09/10/2022 | Servette FC | - | FC Luzern | 1:1 | ||||
| 11. Round | 15/10/2022 | FC Sion | - | FC Luzern | 2:0 | ||||
| 12. Round | 19/10/2022 | FC Luzern | - | FC St. Gallen | 3:3 | ||||
| 13. Round | 22/10/2022 | FC Luzern | - | FC Lugano | 3:1 | ||||
| 14. Round | 29/10/2022 | Grasshopper Club Zürich | - | FC Luzern | 1:3 | ||||
| 15. Round | 05/11/2022 | FC Luzern | - | FC Winterthur | 1:1 | ||||
| 3. Round | 09/11/2022 | FC Luzern | - | FC Basel 1893 | 0:2 | ||||
| 16. Round | 13/11/2022 | BSC Young Boys | - | FC Luzern | 3:0 |
Uruguay