| 2. Round | 12/02/2022 | Rentistas | - | Nacional | 0:4 | ||||
| 3. Round | 21/02/2022 | Nacional | - | Liverpool | 0:0 | ||||
| 4. Round | 27/02/2022 | Peñarol | - | Nacional | 1:0 |  |
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| 5. Round | 13/03/2022 | Nacional | - | Montevideo City Torque | 1:1 | ||||
| 7. Round | 02/04/2022 | Nacional | - | Plaza Colonia | 1:0 | ||||
| 8. Round | 10/04/2022 | Boston River | - | Nacional | 0:6 | ||||
| 12. Round | 14/05/2022 | Defensor Sporting | - | Nacional | 0:2 | ||||
| 13. Round | 21/05/2022 | Nacional | - | Albion | 2:0 |
Uruguay