| 1. Round | 11/02/2022 | Estudiantes II | - | Independiente II | 3:3 | ||||
| 2. Round | 16/02/2022 | Independiente II | - | Arsenal de Sarandí II | 1:1 | ||||
| 3. Round | 20/02/2022 | Vélez Sarsfield II | - | Independiente II | 0:0 | ||||
| 4. Round | 25/02/2022 | Independiente II | - | Boca Juniors II | 1:1 | ||||
| 6. Round | 14/03/2022 | Independiente II | - | Central Córdoba SdE II | 0:1 | ||||
| 7. Round | 22/03/2022 | Independiente II | - | Racing Club II | 2:0 | ||||
| 9. Round | 07/04/2022 | Independiente II | - | Tigre II | 0:1 |
Argentina