| 2. Round | 22/07/2021 | Viktoria Plzeň | - | Dinamo Brest | 2:1 | ||||
| 2. Round | 29/07/2021 | Dinamo Brest | - | Viktoria Plzeň | 1:2 |  |
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| 3. Round | 05/08/2021 | The New Saints | - | Viktoria Plzeň | 4:2 | ||||
| 3. Round | 12/08/2021 | Viktoria Plzeň | - | The New Saints | 4:1 pso | ||||
| Play-offs | 19/08/2021 | Viktoria Plzeň | - | CSKA Sofia | 2:0 | ||||
| Play-offs | 26/08/2021 | CSKA Sofia | - | Viktoria Plzeň | 3:0 aet |
Congo DR