| Group G | 05/04/2022 | Ceará - CE | - | Independiente | 2:1 |  |
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| Group G | 12/04/2022 | Deportivo La Guaira | - | Ceará - CE | 0:2 | ||||
| Group G | 04/05/2022 | Ceará - CE | - | Deportivo La Guaira | 3:0 | |
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| Group G | 17/05/2022 | Ceará - CE | - | General Caballero DJLM | 6:0 | |
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| Group G | 26/05/2022 | Independiente | - | Ceará - CE | 0:2 | |
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| Round of 16 | 06/07/2022 | Ceará - CE | - | The Strongest | 3:0 | ||||
| Quarter-finals | 03/08/2022 | São Paulo FC | - | Ceará - CE | 1:0 | ||||
| Quarter-finals | 10/08/2022 | Ceará - CE | - | São Paulo FC | 3:4 pso | |
Colombia