| 1. Round | 24/07/2021 | CF Pachuca [U18] | - | Club León [U18] | 5:1 | ||||
| 2. Round | 30/07/2021 | Mazatlán FC [U18] | - | CF Pachuca [U18] | 1:1 |  |
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| 3. Round | 09/08/2021 | CF Pachuca [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 4. Round | 14/08/2021 | CF Monterrey [U18] | - | CF Pachuca [U18] | 1:2 | ||||
| 6. Round | 22/08/2021 | Gallos Blancos [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 8. Round | 13/09/2021 | CF Pachuca [U18] | - | Deportivo Toluca [U18] | 2:2 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:4 | ||||
| 10. Round | 23/09/2021 | CF Pachuca [U18] | - | Club Necaxa [U18] | 5:1 | ||||
| 12. Round | 01/10/2021 | Puebla FC [U18] | - | CF Pachuca [U18] | 0:2 | |
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| 13. Round | 16/10/2021 | CF Pachuca [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 15. Round | 25/10/2021 | CF Pachuca [U18] | - | FC Juárez [U18] | 3:0 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U18] | - | CF Pachuca [U18] | 2:2 |
Mexico