| 2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
| 3. Round | 26/07/2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Round | 31/07/2022 | Libertad | - | Resistencia SC | 4:0 | ||||
| 5. Round | 05/08/2022 | Resistencia SC | - | Guaireña FC | 1:2 | ||||
| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 |  |
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| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Round | 10/10/2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 20. Round | 01/11/2022 | General Caballero DJLM | - | Resistencia SC | 1:0 | ||||
| 21. Round | 07/11/2022 | Cerro Porteño | - | Resistencia SC | 1:0 | ||||
| 22. Round | 13/11/2022 | Resistencia SC | - | 12 de Octubre de Itauguá | 0:0 |
Argentina