| 1. Round | 20/08/2020 | Correcaminos UAT | - | Pumas Tabasco | 0:0 | ||||
| 2. Round | 26/08/2020 | Atlético Morelia | - | Pumas Tabasco | 0:2 | ||||
| 3. Round | 03/09/2020 | Pumas Tabasco | - | Mineros de Zacatecas | 3:3 | ||||
| 4. Round | 14/09/2020 | Cimarrones de Sonora | - | Pumas Tabasco | 2:1 | ||||
| 5. Round | 17/09/2020 | Pumas Tabasco | - | Club Celaya | 1:2 | ||||
| 6. Round | 27/09/2020 | Leones Negros | - | Pumas Tabasco | 2:2 |  |
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| 7. Round | 01/10/2020 | Pumas Tabasco | - | Atlante | 0:4 | ||||
| 9. Round | 18/10/2020 | Cancún FC | - | Pumas Tabasco | 4:0 | |
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| 11. Round | 21/10/2020 | TM Fútbol Club | - | Pumas Tabasco | 1:2 | ||||
| 12. Round | 28/10/2020 | Pumas Tabasco | - | Alebrijes de Oaxaca | 0:2 | ||||
| 13. Round | 04/11/2020 | Venados FC | - | Pumas Tabasco | 1:3 | |
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| 14. Round | 11/11/2020 | Pumas Tabasco | - | Tepatitlán | 2:2 | ||||
| 10. Round | 16/11/2020 | Pumas Tabasco | - | Coyotes de Tlaxcala | 0:1 | |
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| 15. Round | 18/11/2020 | Tapatío | - | Pumas Tabasco | 4:2 |
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