| 1. Round | 09/01/2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 | ||||
| 2. Round | 14/01/2022 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 0:1 |  |
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| 3. Round | 23/01/2022 | Pumas UNAM [U20] | - | UANL Tigres [U20] | 2:1 | ||||
| 14. Round | 27/01/2022 | Pumas UNAM [U20] | - | CF Monterrey [U20] | 4:0 | ||||
| 4. Round | 05/02/2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 5. Round | 13/02/2022 | Pumas UNAM [U20] | - | Club León [U20] | 2:1 | ||||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U20] | - | Pumas UNAM [U20] | 0:0 | ||||
| 7. Round | 26/02/2022 | Pumas UNAM [U20] | - | CF América [U20] | 0:1 | ||||
| 8. Round | 02/03/2022 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 9. Round | 27/03/2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Round | 02/04/2022 | FC Juárez [U20] | - | Pumas UNAM [U20] | 3:2 | ||||
| 13. Round | 08/04/2022 | Puebla FC [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 15. Round | 20/04/2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 16. Round | 23/04/2022 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 3:1 | ||||
| 17. Round | 01/05/2022 | Pumas UNAM [U20] | - | CF Pachuca [U20] | 2:1 | |
Mexico