| 1. Round | 15/02/2021 | Rosario Central | - | Argentinos Juniors | 2:1 | ||||
| 2. Round | 21/02/2021 | River Plate | - | Rosario Central | 3:0 | ||||
| 3. Round | 02/03/2021 | Rosario Central | - | Godoy Cruz | 2:2 |  |
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| 4. Round | 08/03/2021 | Racing Club | - | Rosario Central | 1:0 | ||||
| 5. Round | 15/03/2021 | Rosario Central | - | Arsenal de Sarandí | 2:1 | ||||
| 6. Round | 21/03/2021 | Colón de Santa Fe | - | Rosario Central | 0:0 | |
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| 7. Round | 28/03/2021 | Rosario Central | - | Central Córdoba SdE | 2:2 | ||||
| 8. Round | 02/04/2021 | San Lorenzo | - | Rosario Central | 2:0 | ||||
| 9. Round | 11/04/2021 | Rosario Central | - | Banfield | 3:1 | ||||
| 10. Round | 16/04/2021 | Aldosivi | - | Rosario Central | 0:1 | ||||
| 11. Round | 26/04/2021 | Rosario Central | - | Estudiantes | 0:1 | ||||
| 12. Round | 03/05/2021 | Rosario Central | - | Newell's Old Boys | 3:0 | ||||
| 13. Round | 09/05/2021 | Platense | - | Rosario Central | 4:1 |
Argentina