| Group 2 | 14/02/2021 | Alianza | - | Santa Tecla FC | 3:2 | ||||
| Group 2 | 18/02/2021 | AD Chalatenango | - | Alianza | 0:1 |  |
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| Group 2 | 21/02/2021 | Alianza | - | Atlético Marte | 3:2 |  |
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| Group 2 | 07/03/2021 | Santa Tecla FC | - | Alianza | 0:3 | ||||
| Group 2 | 11/03/2021 | Alianza | - | AD Chalatenango | 4:0 | ||||
| Group 2 | 14/03/2021 | Atlético Marte | - | Alianza | 3:5 | |
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| Group A | 20/03/2021 | Jocoro FC | - | Alianza | 1:0 | ||||
| Group A | 01/04/2021 | FAS | - | Alianza | 3:2 | ||||
| Group A | 04/04/2021 | Alianza | - | Luis Ángel Firpo | 1:0 | ||||
| Group A | 11/04/2021 | Alianza | - | Once Municipal | 3:1 | |
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| Group A | 25/04/2021 | Luis Ángel Firpo | - | Alianza | 1:2 | |
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| Group A | 28/04/2021 | Alianza | - | Atlético Marte | 1:2 | |
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| Group A | 01/05/2021 | Once Municipal | - | Alianza | 2:1 | ||||
| Quarter-finals | 05/05/2021 | CD Águila | - | Alianza | 0:1 | ||||
| Quarter-finals | 09/05/2021 | Alianza | - | CD Águila | 2:1 | |
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| Semi-finals | 16/05/2021 | Luis Ángel Firpo | - | Alianza | 1:2 | ||||
| Semi-finals | 23/05/2021 | Alianza | - | Luis Ángel Firpo | 5:4 pso |
Argentina