| 1. Round | 06/01/2022 | Atlético San Luis [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 2. Round | 15/01/2022 | Atlas Guadalajara [U18] | - | Atlético San Luis [U18] | 1:0 | ||||
| 3. Round | 20/01/2022 | Atlético San Luis [U18] | - | FC Juárez [U18] | 1:1 | ||||
| 4. Round | 05/02/2022 | CF América [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 5. Round | 12/02/2022 | Atlético San Luis [U18] | - | Deportivo Toluca [U18] | 3:4 |  |
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| 12. Round | 01/04/2022 | Atlético San Luis [U18] | - | Mazatlán FC [U18] | 3:1 | |
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| 9. Round | 06/04/2022 | Club Tijuana [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 13. Round | 09/04/2022 | Atlético San Luis [U18] | - | Club León [U18] | 2:2 | ||||
| 14. Round | 15/04/2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | |
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| 15. Round | 20/04/2022 | Atlético San Luis [U18] | - | Pumas UNAM [U18] | 2:1 | |
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| 16. Round | 24/04/2022 | Cruz Azul [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 17. Round | 01/05/2022 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 0:1 |
Mexico