| 3. Round | 27/01/2022 | CF América [U20] | - | Atlas Guadalajara [U20] | 3:1 |  |
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| 7. Round | 26/02/2022 | Pumas UNAM [U20] | - | CF América [U20] | 0:1 | |
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| 8. Round | 01/03/2022 | CF América [U20] | - | Gallos Blancos [U20] | 2:0 | ||||
| 9. Round | 05/03/2022 | CF Monterrey [U20] | - | CF América [U20] | 3:2 | |
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| 10. Round | 12/03/2022 | Deportivo Guadalajara [U20] | - | CF América [U20] | 0:2 | ||||
| 11. Round | 20/03/2022 | CF América [U20] | - | Deportivo Toluca [U20] | 2:0 | ||||
| 12. Round | 02/04/2022 | Club Necaxa [U20] | - | CF América [U20] | 1:2 | |
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| 13. Round | 09/04/2022 | CF América [U20] | - | FC Juárez [U20] | 6:0 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U20] | - | CF América [U20] | 4:0 | ||||
| 15. Round | 20/04/2022 | CF América [U20] | - | Club León [U20] | 2:1 | ||||
| 16. Round | 23/04/2022 | UANL Tigres [U20] | - | CF América [U20] | 3:1 |
Mexico