| 1. Round | 04/08/2018 | Portsmouth FC | - | Luton Town | 1:0 | ||||
| 2. Round | 11/08/2018 | Luton Town | - | Sunderland AFC | 1:1 |  |
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| 3. Round | 18/08/2018 | Peterborough United | - | Luton Town | 3:1 | ||||
| 4. Round | 21/08/2018 | Luton Town | - | Southend United | 2:0 | ||||
| 5. Round | 25/08/2018 | Luton Town | - | Shrewsbury Town | 3:2 |  |
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| 7. Round | 08/09/2018 | Doncaster Rovers | - | Luton Town | 2:1 | ||||
| 8. Round | 15/09/2018 | Luton Town | - | Bristol Rovers | 1:0 | ||||
| 9. Round | 22/09/2018 | Blackpool FC | - | Luton Town | 0:0 | ||||
| 10. Round | 29/09/2018 | Luton Town | - | Charlton Athletic | 2:2 | ||||
| 12. Round | 06/10/2018 | Luton Town | - | Scunthorpe United | 3:2 | ||||
| 13. Round | 13/10/2018 | Barnsley FC | - | Luton Town | 3:2 | ||||
| 14. Round | 20/10/2018 | Luton Town | - | Walsall FC | 2:0 | |
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| 15. Round | 23/10/2018 | Luton Town | - | Accrington Stanley | 4:1 | |
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| 18. Round | 17/11/2018 | Luton Town | - | Plymouth Argyle | 5:1 | ||||
| 20. Round | 27/11/2018 | Luton Town | - | Bradford City | 4:0 | ||||
| 23. Round | 22/12/2018 | Luton Town | - | Burton Albion | 2:0 | ||||
| 24. Round | 26/12/2018 | Scunthorpe United | - | Luton Town | 0:2 |
England