| 3. Round | 24/07/2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
| 4. Round | 31/07/2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 6. Round | 14/08/2022 | Club Olimpia | - | Cerro Porteño | 2:0 | ||||
| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Round | 04/09/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 |  |
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| 11. Round | 16/09/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 12. Round | 20/09/2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 14. Round | 02/10/2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
| 19. Round | 27/10/2022 | Resistencia SC | - | Club Olimpia | 1:6 |  |
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| 20. Round | 30/10/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 3:1 | ||||
| 21. Round | 08/11/2022 | Sol de América | - | Club Olimpia | 0:2 |
Paraguay