| 3. Round | 11/08/2021 | Coyotes de Tlaxcala | - | Alebrijes de Oaxaca | 1:1 | ||||
| 4. Round | 18/08/2021 | Alebrijes de Oaxaca | - | Tepatitlán | 2:3 |  |
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| 5. Round | 29/08/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 | ||||
| 6. Round | 01/09/2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 | |
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| 7. Round | 09/09/2021 | Dorados de Sinaloa | - | Alebrijes de Oaxaca | 2:1 | ||||
| 8. Round | 14/09/2021 | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 2:1 | |
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| 9. Round | 24/09/2021 | Atlético Morelia | - | Alebrijes de Oaxaca | 1:0 | ||||
| 10. Round | 29/09/2021 | Alebrijes de Oaxaca | - | Tapatío | 0:1 | |
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| 11. Round | 06/10/2021 | Venados FC | - | Alebrijes de Oaxaca | 1:1 | ||||
| 12. Round | 13/10/2021 | Alebrijes de Oaxaca | - | TM Fútbol Club | 2:2 | ||||
| 13. Round | 20/10/2021 | Club Celaya | - | Alebrijes de Oaxaca | 1:0 | ||||
| 14. Round | 26/10/2021 | Alebrijes de Oaxaca | - | Atlante | 0:0 | |
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| 15. Round | 03/11/2021 | Alebrijes de Oaxaca | - | Correcaminos UAT | 2:1 | ||||
| 16. Round | 10/11/2021 | Cancún FC | - | Alebrijes de Oaxaca | 1:2 |
Mexico