| 1. Round | 19/01/2022 | Club León [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 5. Round | 13/02/2022 | Pumas UNAM [U18] | - | Club León [U18] | 0:0 | ||||
| 7. Round | 25/02/2022 | Club Necaxa [U18] | - | Club León [U18] | 2:0 | ||||
| 12. Round | 03/04/2022 | Club León [U18] | - | Gallos Blancos [U18] | 2:1 | ||||
| 14. Round | 16/04/2022 | Club León [U18] | - | Puebla FC [U18] | 5:4 | ||||
| 15. Round | 20/04/2022 | CF América [U18] | - | Club León [U18] | 5:1 | ||||
| 16. Round | 24/04/2022 | Santos Laguna [U18] | - | Club León [U18] | 2:3 |  |
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| 17. Round | 01/05/2022 | Club León [U18] | - | Deportivo Toluca [U18] | 0:0 |
Mexico