5. Round | 16/10/2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | ||||
7. Round | 30/10/2021 | Santos Laguna [] | - | Club Necaxa [] | 0:2 | ||||
8. Round | 05/11/2021 | UANL Tigres [] | - | Santos Laguna [] | 3:1 | ||||
9. Round | 13/11/2021 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:2 | ||||
10. Round | 20/11/2021 | Club León [] | - | Santos Laguna [] | 4:2 |