| 1. Round | 09/01/2022 | Pumas UNAM [U18] | - | Deportivo Toluca [U18] | 1:0 |  |
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| 4. Round | 05/02/2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 |  |
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| 5. Round | 13/02/2022 | Pumas UNAM [U18] | - | Club León [U18] | 0:0 | ||||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U18] | - | Pumas UNAM [U18] | 5:2 | ||||
| 7. Round | 26/02/2022 | Pumas UNAM [U18] | - | CF América [U18] | 0:1 | ||||
| 8. Round | 02/03/2022 | Santos Laguna [U18] | - | Pumas UNAM [U18] | 0:0 | ||||
| 10. Round | 11/03/2022 | Cruz Azul [U18] | - | Pumas UNAM [U18] | 0:2 | |
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| 11. Round | 19/03/2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 12. Round | 02/04/2022 | FC Juárez [U18] | - | Pumas UNAM [U18] | 1:2 | |
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| 13. Round | 08/04/2022 | Puebla FC [U18] | - | Pumas UNAM [U18] | 2:4 | ||||
| 15. Round | 20/04/2022 | Atlético San Luis [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 16. Round | 23/04/2022 | Deportivo Guadalajara [U18] | - | Pumas UNAM [U18] | 1:2 | |
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| 17. Round | 01/05/2022 | Pumas UNAM [U18] | - | CF Pachuca [U18] | 0:1 |
Mexico