| 2. Round | 14/01/2022 | Gallos Blancos [U18] | - | Pumas UNAM [U18] | 0:3 |  |
|||
| 3. Round | 23/01/2022 | Pumas UNAM [U18] | - | UANL Tigres [U18] | 1:4 | ||||
| 14. Round | 27/01/2022 | Pumas UNAM [U18] | - | CF Monterrey [U18] | 4:2 | ||||
| 4. Round | 05/02/2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 5. Round | 13/02/2022 | Pumas UNAM [U18] | - | Club León [U18] | 0:0 |  |
|||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U18] | - | Pumas UNAM [U18] | 5:2 | |
|||
| 7. Round | 26/02/2022 | Pumas UNAM [U18] | - | CF América [U18] | 0:1 | ||||
| 10. Round | 11/03/2022 | Cruz Azul [U18] | - | Pumas UNAM [U18] | 0:2 | |
|
||
| 11. Round | 19/03/2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 3:0 | |
|||
| 12. Round | 02/04/2022 | FC Juárez [U18] | - | Pumas UNAM [U18] | 1:2 | ||||
| 13. Round | 08/04/2022 | Puebla FC [U18] | - | Pumas UNAM [U18] | 2:4 | |
|||
| 15. Round | 20/04/2022 | Atlético San Luis [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 16. Round | 23/04/2022 | Deportivo Guadalajara [U18] | - | Pumas UNAM [U18] | 1:2 | |
|||
| 17. Round | 01/05/2022 | Pumas UNAM [U18] | - | CF Pachuca [U18] | 0:1 |
Mexico