| 2. Round | 02/08/2021 | Atlético San Luis [U20] | - | Gallos Blancos [U20] | 0:2 | ||||
| 4. Round | 12/08/2021 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 8. Round | 10/09/2021 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:0 | ||||
| 14. Round | 21/09/2021 | FC Juárez [U20] | - | Atlético San Luis [U20] | 1:2 | ||||
| 12. Round | 02/10/2021 | Club León [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 13. Round | 16/10/2021 | Atlético San Luis [U20] | - | CF América [U20] | 1:0 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 16. Round | 31/10/2021 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 3:1 |  |
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| 5. Round | 03/11/2021 | CF Pachuca [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 17. Round | 07/11/2021 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 2:1 |
Mexico