| 6. Round | 28/08/2022 | Union Saint-Gilloise | - | RSC Anderlecht | 2:1 |  |
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| 5. Round | 31/08/2022 | Royal Antwerp FC | - | Union Saint-Gilloise | 4:2 | ||||
| 7. Round | 04/09/2022 | SV Zulte Waregem | - | Union Saint-Gilloise | 1:3 | ||||
| 8. Round | 11/09/2022 | Union Saint-Gilloise | - | KRC Genk | 1:2 | ||||
| 9. Round | 18/09/2022 | KAS Eupen | - | Union Saint-Gilloise | 1:2 | ||||
| 10. Round | 01/10/2022 | Oud-Heverlee Leuven | - | Union Saint-Gilloise | 0:3 | ||||
| 12. Round | 16/10/2022 | KV Oostende | - | Union Saint-Gilloise | 1:6 | |
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| 13. Round | 19/10/2022 | Union Saint-Gilloise | - | KAA Gent | 2:0 | ||||
| 14. Round | 22/10/2022 | Union Saint-Gilloise | - | Club Brugge KV | 2:2 |
Spain