| 1. Round | 08/01/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 |  |
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| 2. Round | 15/01/2022 | Cruz Azul [U18] | - | FC Juárez [U18] | 1:0 | ||||
| 3. Round | 22/01/2022 | CF Monterrey [U18] | - | Cruz Azul [U18] | 1:0 | ||||
| 4. Round | 07/02/2022 | Club León [U18] | - | Cruz Azul [U18] | 1:0 |  |
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| 5. Round | 12/02/2022 | Cruz Azul [U18] | - | Club Necaxa [U18] | 2:1 | ||||
| 6. Round | 20/02/2022 | Deportivo Toluca [U18] | - | Cruz Azul [U18] | 1:1 | ||||
| 7. Round | 27/02/2022 | Cruz Azul [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 8. Round | 02/03/2022 | UANL Tigres [U18] | - | Cruz Azul [U18] | 2:0 | ||||
| 10. Round | 11/03/2022 | Cruz Azul [U18] | - | Pumas UNAM [U18] | 0:2 | ||||
| 11. Round | 19/03/2022 | CF Pachuca [U18] | - | Cruz Azul [U18] | 3:2 | ||||
| 12. Round | 02/04/2022 | Cruz Azul [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 15. Round | 21/04/2022 | Gallos Blancos [U18] | - | Cruz Azul [U18] | 1:1 | ||||
| 16. Round | 24/04/2022 | Cruz Azul [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 17. Round | 30/04/2022 | CF América [U18] | - | Cruz Azul [U18] | 3:2 |
Venezuela
Mexico