| 1. Round | 10/08/2015 | Southampton FC U21 | - | Manchester City U21 | 2:2 | ||||
| 2. Round | 14/08/2015 | Chelsea FC U21 | - | Southampton FC U21 | 1:3 | ||||
| 3. Round | 24/08/2015 | Southampton FC U21 | - | Middlesbrough FC U21 | 1:1 | ||||
| 4. Round | 14/09/2015 | Southampton FC U21 | - | Leicester City U21 | 3:1 | ||||
| 5. Round | 21/09/2015 | Reading FC U21 | - | Southampton FC U21 | 2:5 |  |
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| 6. Round | 28/09/2015 | Southampton FC U21 | - | Sunderland AFC U21 | 0:2 | ||||
| 8. Round | 26/10/2015 | Southampton FC U21 | - | Everton FC U21 | 0:2 | ||||
| 11. Round | 30/11/2015 | Norwich City U21 | - | Southampton FC U21 | 7:2 | ||||
| 14. Round | 11/01/2016 | Southampton FC U21 | - | Liverpool FC U21 | 1:2 | ||||
| 7. Round | 18/01/2016 | Manchester United U21 | - | Southampton FC U21 | 4:0 | ||||
| 17. Round | 09/02/2016 | Southampton FC U21 | - | Tottenham Hotspur U21 | 1:1 |
England