| 1. Round | 24/07/2021 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 1:5 | ||||
| 2. Round | 02/08/2021 | Atlético San Luis [U20] | - | Gallos Blancos [U20] | 0:2 | ||||
| 4. Round | 12/08/2021 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 8. Round | 10/09/2021 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 13. Round | 16/10/2021 | Atlético San Luis [U20] | - | CF América [U20] | 1:0 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U20] | - | Atlas Guadalajara [U20] | 0:2 |  |
|||
| 16. Round | 31/10/2021 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 5. Round | 03/11/2021 | CF Pachuca [U20] | - | Atlético San Luis [U20] | 1:3 |
Mexico