| 2. Round | 14/01/2022 | Club Necaxa [U20] | - | CF Monterrey [U20] | 1:1 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:1 | ||||
| 7. Round | 25/02/2022 | Club Necaxa [U20] | - | Club León [U20] | 0:3 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 10. Round | 11/03/2022 | Club Necaxa [U20] | - | Gallos Blancos [U20] | 2:1 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 |
Mexico