| 4. Round | 21/08/2005 | Pumas UNAM | - | Club San Luis | 0:0 | ||||
| 5. Round | 25/08/2005 | Club San Luis | - | Atlante | 2:2 | ||||
| 6. Round | 28/08/2005 | UANL Tigres | - | Club San Luis | 1:0 |  |
|||
| 7. Round | 11/09/2005 | Club San Luis | - | Dorados de Sinaloa | 4:1 |  |
|||
| 8. Round | 18/09/2005 | Santos Laguna | - | Club San Luis | 3:1 |  |
|||
| 10. Round | 29/09/2005 | Club Necaxa | - | Club San Luis | 2:1 | |
|||
| 11. Round | 02/10/2005 | CF América | - | Club San Luis | 3:1 | |
|||
| 12. Round | 16/10/2005 | Club San Luis | - | Veracruz (old) | 1:0 | ||||
| 13. Round | 22/10/2005 | Cruz Azul | - | Club San Luis | 3:0 | ||||
| 14. Round | 30/10/2005 | Club San Luis | - | CF Monterrey | 1:2 | |
|||
| 15. Round | 06/11/2005 | CF Pachuca | - | Club San Luis | 0:0 | ||||
| 16. Round | 20/11/2005 | Club San Luis | - | Monarcas Morelia | 2:1 | |
Argentina
Italy