| 1. Round | 23/07/2021 | Club Necaxa [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 2. Round | 01/08/2021 | Santos Laguna [U18] | - | Cruz Azul [U18] | 1:2 | ||||
| 3. Round | 07/08/2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 4. Round | 15/08/2021 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 14. Round | 15/09/2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 15. Round | 24/10/2021 | Santos Laguna [U18] | - | Deportivo Toluca [U18] | 3:1 | ||||
| 16. Round | 30/10/2021 | Gallos Blancos [U18] | - | Santos Laguna [U18] | 1:1 |
Mexico