| 2. Round | 23/07/2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Round | 26/07/2021 | Vélez Sarsfield II | - | Defensa y Justicia II | 0:0 | ||||
| 4. Round | 30/07/2021 | Defensa y Justicia II | - | Gimnasia de La Plata II | 0:5 | ||||
| 5. Round | 06/08/2021 | Aldosivi II | - | Defensa y Justicia II | 1:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Round | 17/11/2021 | Unión de Santa Fe II | - | Defensa y Justicia II | 1:1 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 |
Argentina