| 3. Round | 19/02/2018 | Club Nacional | - | 3 de Febrero | 0:0 | ||||
| 4. Round | 25/02/2018 | General Díaz | - | Club Nacional | 1:2 | ||||
| 5. Round | 02/03/2018 | Club Nacional | - | Sol de América | 1:1 | ||||
| 6. Round | 12/03/2018 | Sportivo Luqueño | - | Club Nacional | 1:3 | ||||
| 8. Round | 18/03/2018 | Guaraní | - | Club Nacional | 1:4 | ||||
| 7. Round | 21/03/2018 | Club Nacional | - | Libertad | 1:1 | ||||
| 9. Round | 26/03/2018 | Club Nacional | - | Deportivo Capiatá | 4:0 | ||||
| 10. Round | 01/04/2018 | Deportivo Santaní | - | Club Nacional | 1:1 | ||||
| 11. Round | 07/04/2018 | Club Nacional | - | Club Olimpia | 0:0 | ||||
| 12. Round | 14/04/2018 | Cerro Porteño | - | Club Nacional | 5:0 |
Paraguay