| 1. Round | 09/01/2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 | ||||
| 3. Round | 21/01/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 |  |
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| 5. Round | 12/02/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 6. Round | 20/02/2022 | Deportivo Toluca [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 7. Round | 24/02/2022 | Gallos Blancos [U20] | - | Deportivo Toluca [U20] | 0:1 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 |  |
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| 10. Round | 13/03/2022 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 11. Round | 20/03/2022 | CF América [U20] | - | Deportivo Toluca [U20] | 2:0 | ||||
| 12. Round | 03/04/2022 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 2:0 | |
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| 17. Round | 01/05/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 3:1 |
Mexico