| 5. Round | 12/02/2022 | Deportivo Guadalajara [U18] | - | UANL Tigres [U18] | 3:0 | ||||
| 6. Round | 19/02/2022 | Club León [U18] | - | Deportivo Guadalajara [U18] | 2:1 | ||||
| 7. Round | 26/02/2022 | Deportivo Guadalajara [U18] | - | Puebla FC [U18] | 3:0 |  |
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| 9. Round | 05/03/2022 | Deportivo Guadalajara [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 10. Round | 12/03/2022 | Deportivo Guadalajara [U18] | - | CF América [U18] | 3:2 |  |
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| 11. Round | 20/03/2022 | Atlas Guadalajara [U18] | - | Deportivo Guadalajara [U18] | 0:0 |  |
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| 4. Round | 29/03/2022 | FC Juárez [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 12. Round | 02/04/2022 | Deportivo Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 | |
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| 13. Round | 09/04/2022 | Deportivo Toluca [U18] | - | Deportivo Guadalajara [U18] | 3:3 | |
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| 14. Round | 16/04/2022 | Cruz Azul [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 15. Round | 19/04/2022 | Deportivo Guadalajara [U18] | - | Club Tijuana [U18] | 2:2 | |
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| 16. Round | 23/04/2022 | Deportivo Guadalajara [U18] | - | Pumas UNAM [U18] | 1:2 | ||||
| 17. Round | 29/04/2022 | Club Necaxa [U18] | - | Deportivo Guadalajara [U18] | 1:3 |
Mexico