| 1. Round | 07/11/2021 | Anagennisi Karditsa | - | Thesprotos | 1:0 | ||||
| 3. Round | 21/11/2021 | Anagennisi Karditsa | - | Almopos Arideas | 4:0 |  |
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| 4. Round | 25/11/2021 | Niki Volou FC | - | Anagennisi Karditsa | 1:0 | ||||
| 5. Round | 28/11/2021 | Anagennisi Karditsa | - | Olympiakos Volou | 4:0 | ||||
| 16. Round | 30/01/2022 | Anagennisi Karditsa | - | Pierikos Katerini | 2:0 | ||||
| 11. Round | 02/02/2022 | Anagennisi Karditsa | - | Panserraikos | 1:0 | |
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| 17. Round | 06/02/2022 | Xanthi FC | - | Anagennisi Karditsa | 5:2 | |
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| 18. Round | 13/02/2022 | Thesprotos | - | Anagennisi Karditsa | 0:0 | ||||
| 19. Round | 16/02/2022 | Anagennisi Karditsa | - | AO Kavala | 1:0 | |
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| 20. Round | 20/02/2022 | Almopos Arideas | - | Anagennisi Karditsa | 1:0 | ||||
| 12. Round | 23/02/2022 | AEP Iraklis FC | - | Anagennisi Karditsa | 1:1 |  |
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| 13. Round | 02/03/2022 | Anagennisi Karditsa | - | Veria FC | 5:2 | |
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| 22. Round | 06/03/2022 | Olympiakos Volou | - | Anagennisi Karditsa | 0:1 | |
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| 25. Round | 19/03/2022 | Anagennisi Karditsa | - | AE Lárissa | 2:3 |  |
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| 30. Round | 10/04/2022 | Veria FC | - | Anagennisi Karditsa | 2:0 |
Argentina