| 2. Round | 20/01/2021 | Alebrijes de Oaxaca | - | Tepatitlán | 0:1 | ||||
| 3. Round | 28/01/2021 | Alebrijes de Oaxaca | - | Tapatío | 2:1 | ||||
| 4. Round | 02/02/2021 | Coyotes de Tlaxcala | - | Alebrijes de Oaxaca | 2:1 |  |
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| 1. Round | 06/02/2021 | Venados FC | - | Alebrijes de Oaxaca | 2:2 | ||||
| 5. Round | 09/02/2021 | Alebrijes de Oaxaca | - | Pumas Tabasco | 3:1 | ||||
| 6. Round | 20/02/2021 | Atlético Morelia | - | Alebrijes de Oaxaca | 6:3 | |
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| 7. Round | 24/02/2021 | Alebrijes de Oaxaca | - | Correcaminos UAT | 2:2 | ||||
| 8. Round | 04/03/2021 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 2:0 |  |
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| 9. Round | 09/03/2021 | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 4:3 | |
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| 10. Round | 18/03/2021 | Atlante | - | Alebrijes de Oaxaca | 1:1 | ||||
| 11. Round | 24/03/2021 | Alebrijes de Oaxaca | - | Cancún FC | 0:0 | ||||
| 12. Round | 27/03/2021 | Club Celaya | - | Alebrijes de Oaxaca | 0:0 | ||||
| 13. Round | 31/03/2021 | Dorados de Sinaloa | - | Alebrijes de Oaxaca | 1:1 | ||||
| 14. Round | 07/04/2021 | Alebrijes de Oaxaca | - | TM Fútbol Club | 4:1 | ||||
| 15. Round | 14/04/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 |
Mexico