| 4. Round | 16/07/2022 | Cruz Azul [] | - | CF América [] | 3:2 | ||||
| 5. Round | 24/07/2022 | CF América [] | - | Gallos Blancos [] | 2:2 |  |
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| 6. Round | 30/07/2022 | Deportivo Toluca [] | - | CF América [] | 2:1 | ||||
| 7. Round | 06/08/2022 | CF América [] | - | Club Necaxa [] | 1:0 | ||||
| 3. Round | 10/08/2022 | CF América [] | - | Puebla FC [] | 4:3 | |
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| 8. Round | 13/08/2022 | Pumas UNAM [] | - | CF América [] | 3:0 | ||||
| 9. Round | 20/08/2022 | CF América [] | - | CF Pachuca [] | 2:2 | ||||
| 10. Round | 27/08/2022 | CF América [] | - | FC Juárez [] | 5:0 | ||||
| 1. Round | 31/08/2022 | FC Juárez [] | - | CF América [] | 2:0 |  |
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| 12. Round | 10/09/2022 | Puebla FC [] | - | CF América [] | 1:4 | ||||
| 13. Round | 17/09/2022 | CF América [] | - | Cruz Azul [] | 1:1 | ||||
| 14. Round | 24/09/2022 | Gallos Blancos [] | - | CF América [] | 0:1 | ||||
| 15. Round | 01/10/2022 | CF América [] | - | Deportivo Toluca [] | 2:1 | ||||
| 16. Round | 09/10/2022 | Club Necaxa [] | - | CF América [] | 5:2 | ||||
| 17. Round | 15/10/2022 | CF América [] | - | Pumas UNAM [] | 2:1 | ||||
| 18. Round | 23/10/2022 | CF Pachuca [] | - | CF América [] | 2:1 |
Mexico