| 22. Round | 20/02/1988 | SV Meppen | - | Rot-Weiss Essen | 1:1 |  |
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| 23. Round | 27/02/1988 | Rot-Weiss Essen | - | Arminia Bielefeld | 1:1 | ||||
| 24. Round | 05/03/1988 | SG Wattenscheid 09 | - | Rot-Weiss Essen | 1:0 | ||||
| 25. Round | 12/03/1988 | Rot-Weiss Essen | - | SV Darmstadt 98 | 2:1 | ||||
| 26. Round | 19/03/1988 | Stuttgarter Kickers | - | Rot-Weiss Essen | 4:1 | |
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| 27. Round | 26/03/1988 | Rot-Weiss Essen | - | FC St. Pauli | 2:2 | ||||
| 28. Round | 29/03/1988 | Blau-Weiß 90 Berlin | - | Rot-Weiss Essen | 1:1 | ||||
| 29. Round | 02/04/1988 | Rot-Weiss Essen | - | Rot-Weiß Oberhausen | 2:1 | |
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| 30. Round | 09/04/1988 | SSV Ulm 1846 | - | Rot-Weiss Essen | 1:3 | ||||
| 31. Round | 16/04/1988 | Rot-Weiss Essen | - | SG Union Solingen | 1:2 | ||||
| 32. Round | 23/04/1988 | VfL Osnabrück | - | Rot-Weiss Essen | 1:1 | ||||
| 33. Round | 04/05/1988 | Rot-Weiss Essen | - | 1. FC Saarbrücken | 1:1 | ||||
| 34. Round | 07/05/1988 | SpVgg Bayreuth | - | Rot-Weiss Essen | 3:2 | ||||
| 35. Round | 14/05/1988 | Rot-Weiss Essen | - | Alemannia Aachen | 4:0 | ||||
| 36. Round | 18/05/1988 | Kickers Offenbach | - | Rot-Weiss Essen | 2:0 | ||||
| 37. Round | 24/05/1988 | Rot-Weiss Essen | - | Fortuna Köln | 1:0 |
Germany