| 2. Round | 15/02/2022 | Atlético Tucumán II | - | Platense II | 3:1 | ||||
| 3. Round | 20/02/2022 | Platense II | - | Sarmiento de Junín II | 1:1 | ||||
| 4. Round | 27/02/2022 | Platense II | - | Banfield II | 1:2 | ||||
| 6. Round | 11/03/2022 | Platense II | - | Patronato de Paraná II | 0:2 |  |
|||
| 5. Round | 28/03/2022 | Unión de Santa Fe II | - | Platense II | 0:4 | ||||
| 9. Round | 08/04/2022 | Platense II | - | Racing Club II | 1:0 | ||||
| 11. Round | 20/04/2022 | Platense II | - | Gimnasia de La Plata II | 1:0 |
Argentina