| 1. Round | 16/07/2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 2. Round | 23/07/2021 | Colón de Santa Fe II | - | Lanús II | 0:1 | ||||
| 3. Round | 27/07/2021 | Huracán II | - | Colón de Santa Fe II | 0:1 | ||||
| 4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
| 5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
| 6. Round | 13/08/2021 | Colón de Santa Fe II | - | Gimnasia de La Plata II | 2:1 |  |
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| 7. Round | 20/08/2021 | Aldosivi II | - | Colón de Santa Fe II | 1:2 | ||||
| 8. Round | 24/08/2021 | Colón de Santa Fe II | - | Sarmiento de Junín II | 1:0 | ||||
| 9. Round | 27/08/2021 | Independiente II | - | Colón de Santa Fe II | 0:0 |
Argentina