| 4. Round | 30/07/2021 | Rosario Central II | - | Aldosivi II | 4:1 | ||||
| 9. Round | 30/08/2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 11. Round | 14/09/2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 | ||||
| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina