| 1. Round | 25/07/2021 | Club Tijuana [U18] | - | UANL Tigres [U18] | 1:0 | ||||
| 4. Round | 13/08/2021 | FC Juárez [U18] | - | Club Tijuana [U18] | 3:2 |  |
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| 7. Round | 27/08/2021 | Club Tijuana [U18] | - | CF Monterrey [U18] | 0:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 15. Round | 24/10/2021 | Pumas UNAM [U18] | - | Club Tijuana [U18] | 2:2 | |
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| 16. Round | 28/10/2021 | Atlas Guadalajara [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U18] | - | CF Pachuca [U18] | 2:2 |
Mexico