| 5. Round | 06/08/2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 |  |
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| 7. Round | 22/08/2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Round | 25/08/2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 | ||||
| 14. Round | 03/10/2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 15. Round | 08/10/2021 | Estudiantes | - | Rosario Central | 2:2 | ||||
| 19. Round | 31/10/2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | |
Argentina