| 1. Round | 16/07/2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 |  |
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| 3. Round | 27/07/2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 4. Round | 30/07/2021 | Rosario Central II | - | Aldosivi II | 4:1 | ||||
| 16. Round | 13/10/2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | ||||
| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina